1002/9781119374312.ch1, Downloaded from by Turkey Cochrane Evidence Aid, Wiley Online Library on [21/02/2024]. See the Terms and Conditions ( on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License InTroducTIon To Fungal PhysIology 20 Table 1.9 Modes of nutrient transport in fungi. Mode of nutrient transport examples of nutrients transported description organic acids, shortchain alkanes, and longchain fatty acids by fungi and export of lipophilic metabolites (e.g. ethanol) and gaseous compounds)

Free diffusion Passive penetration of lipidsoluble solutes through plasma membrane following the law of mass action from a high extracellular concentration to a lower intracellular concentration In the yeast S. cerevisiae, glucose is transported in this manner Translocates solutes down a transmembrane concentration gradient in an enzyme (permease) mediated manner. as with passive diffusion, nutrient translocation continues until intracellular concentration equals that of the extracellular medium Facilitated diffusion These operate as voltagedependent gates to transiently move certain nutrient ions down concentration gradients. They are normally closed at the negative membrane potential of resting yeast cells but open when the membrane potential becomes positive

The latter extrudes protons using the free energy of aTP hydrolysis that enables nutrients to enter either with influxed protons, as in symport mechanisms, or against effluxed protons, as in antiport mechanisms active transport Many nutrients (sugars, amino acids, ions) and complete oxidation of glucose 6phosphate would result in: glucose -phosphate nadPh 12 co 6 6 nadP 12 12

g. ethanol, glycerol, succinate, and acetate) may lead to gluconeogenesis (conversion of pyruvate to glucose) and polysaccharide biosynthesis. gluconeogenesis may be regarded as a reversal of glycolysis and requires aTP as energy and nadh as reducing power. 10.1002/9781119374312.ch1, Downloaded from by Turkey Cochrane Evidence Aid, Wiley Online Library on [21/02/2024]. See the Terms and Conditions ( on Wiley Online Library for rules of use; OA articles are governed by the applicable Creative Commons License