V. Frolkis); the concept of vitauktu (antiageing) processes that counteract ageing (V.V. Frolkis); principles of gene-regulatory therapy (V.V. Frolkis and his school); the concept of the existence of an active factor in old age that suppresses the functions of various body systems (G.M. Butenko); ideas about the role of mechanisms of neurohumoral regulation, the hypothalamus, agerelated changes in the immune system and metabolism, intracellular regulators inverters, apoptosis, ionizing radiation in ageing processes (V.V. Frolkis, V.V. Bezrukov, N.S.Verkhratsky et al.) ; a balance theory of ageing (V.P. Voytenko); provisions on age-related impairment of mitochondrial activity due to changes in the regulation of their functions by the cell nucleus (O.Ya. Litoshenko); new means and methods of experimental life extension (V.V. Frolkis, H.K. Muradyan,

V.V. Bezrukov et al.); the concept of biological age and the methodology of its determination (M.K. Witte, V.P. Voytenko, A.V. Tokar et al.); ideas about the relationship between genetic and environmental factors in the formation of longevity (D.F. Chebotaryov, V.V. Bezrukov, V.P. Voytenko et al.). Main developments in the field of Clinical Gerontology and Geriatrics:

F. Chebotaryov, O.V. Korkushko, M.B. Mankovskyi et al.); methods of determining the biological age of the organism and the partial functional age of various systems for the diagnosis of accelerated human ageing and determining the variant of its development, for forecasting the course of diseases and expected life expectancy, for evaluating the effectiveness of geroprotective agents (V.P. Voytenko, A.V. Tokar, O. M. Polyukhov et al.); means for the prevention of accelerated ageing and the correction of functions of the body disturbed during ageing (O.V. Korkushko, V.I. Molotkov, O.G. Kalinovska et al.);

F. Chebotaryov, O.V. Korkushko, L.M. Yena et al.), diseases of the respiratory system (O.V. Korkushko, L.O. Ivanov, E.O. Asanov, M.D. Chebotaryov), gastrointestinal tract (O.V. Korkushko, D.M. Yakymenko, V.P. Tereshchenko, et al.), disorders of cerebral circulation, Parkinson's and Alzheimer's diseases (M.B. Mankovskyi, O.B. Vainshtok, I.M. Karaban, et al.), osteoporosis, osteochondrosis and osteoarthritis (E.P. Podrushnyak, V.V. Povoroznyuk, N.V. Grigoryeva et al.). 65 The main achievements of the institute in the field of Social Gerontology and Gerohygiene: